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Randen L. Patterson

Assistant Professor of Biology

230 Life Sciences
Phone: 865-1668
Lab Address: 225 Life Sciences
Lab Phone: 865-2847
Email:

Education:

  1. Ph.D. University of Maryland 1997-2000

Postdoc Training:

  1. Post-doctoral Fellowship with Dr. Solomon H. Snyder, Johns Hopkins University 2000-2004

Honors and Awards:

  1. National Research Service Award 9/01-9/04 NIH, Neuroscience Post-doctoral Training Grant: Awarded to Randen L. Patterson Johns Hopkins University School of Medicine
  2. Pre-doctoral Traineeship 7/99-7/00 Awarded from the Muscle Biology Training Program NIH, NIAMS, Institutional Training Grant: awarded to Martin Schneider

Research Interests:

Receptor-operated Calcium Signaling Pathways

Our lab focuses on receptor-operated calcium signaling.  We investigate the function of the inositol tris-phosphate receptor and the TRP channel superfamily of proteins within neuronal G-protein coupled and tyrosine-kinase coupled receptor pathways. The lab is also refining the gestalt domain detection algorithm (GDDA) which was recently developed by Dr. Patterson here at Penn State University and Dr. van Rossum at Johns Hopkins University.  The manuscript describing the GDDA will be appearing an Nature in March 2005. This algorithm can identify functional domains within proteins which have highly divergent sequences. We are rapidly expanding our research using the GDDA to investigate the molecular evolution of protein domains, with lipid binding domains being of special interest.

Selected Publications:

  • 1. Patterson RL, van Rossum DB, Kaplin AI, Barrow RK, Snyder SH. "Inositol 1,4,5-trisphosphate receptor/GAPDH complex augments Ca2+ release via locally d
  • 2. Bandyopadhyay BC, Swaim WD, Liu X, Redman R, Patterson RL, Ambudkar IS. "Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells: role in apical
  • 3. Boehning D, van Rossum DB, Patterson RL, Snyder SH. "A peptide inhibitor of cytochrome c/inositol 1,4,5-trisphosphate receptor bindin
  • 4. Patterson RL*, van Rossum DB*, Barrow RK, Snyder SH. (* co-author) "RACK1 binds to inositol 1
  • 5. van Rossum DB*, Patterson RL*, Kiselyov K, Boehning D, Barrow RK, Gill DL, Snyder SH. (*co-author) "Agonist-induced Ca2+ entry determ
  • 6. Gill DL, Patterson RL. Toward a consensus on the operation of receptor-induced calcium entry signals. Sci STKE. 2004 Jul 20;2004(243):pe39
  • 7. Patterson RL, Snyder SH. "Inositol 1,4,5 Triphosphate (InsP3) Receptors: Multiple Signal Integrators" Annual Reviews of Biochemi
  • 8. Choi JH, Park JB, Bae SS, Yun S, Kim HS, Hong WP, Kim IS, Kim JH, Han MY, Ryu SH, Patterson RL, Snyder SH, Suh PG. "Phospholipase C-g
  • 9.Spassova MA, Soboloff J, He LP, Hewavitharana T, Xu W, Venkatachalam K, van Rossum DB, Patterson RL, Gill DL.
  • 10. Boehning D, Patterson RL, Snyder SH "Apoptosis And Calcium: New Roles For Cytochrome c And Inositol 1,4,5-Trisphosphate." Cell
  • 11. Boehning D*, Patterson RL*, Sedaghat L, Glebova NO, Kurosaki T, Snyder SH. (*co-author) "Cyt
  • 12. Patterson RL*, van Rossum DB*, Ford DL, Bae SS, Suh P-G, Kurosaki T, Snyder SH, and Gill DL. (* co-author)"Phospholipase C-
  • 13. Venkatachalam K, van Rossum DB, Patterson RL, Ma HT, Gill DL. "The cellular and molecular basis of store-operated calcium entry.&quo
  • 14. Ma HT, Venkatachalam K, Li HS, Montell C, Kurosaki T, Patterson RL, Gill DL "Assessment of the role of the1,4,5-trisphosphate recept
  • 15. van Rossum DB*, Patterson RL*, Ma HT, and Gill DL (*co-author) "Ca2+ entry mediated by store depletion, S-nitrosylation, and TRP3 ch
  • 16. Ma HT *, Patterson RL *, van Rossum DB, Birnbaumer L, Mikoshiba K, Gill DL (* co-author) "Re
  • 17. Patterson RL, van Rossum DB, and Gill DL. "Store-Operated Calcium Entry: Evidence for a Secretion-like Model" Cell, 98:4, 487-4
  • 18. Ma HT, Favre CJ, Patterson RL, Stone MR, and Gill DL "Ca2+ Entry Activated by S-Nitrosylation" Journal of Biological Chemistry,
  • 19. Khurana S, Arpin M, Patterson RL, and Donowitz M "Ileal Microvillar Protein Villin is Tyrosine phosphorylated and Associated with PL

  • MANUSCRIPTS IN PRESS/PREPARATION
    1. van Rossum DB*, Patterson RL*, Sharma S, Barrow RK, Kornberg M, Gill DL and Snyder SH (co-author) "PLC-g1 Controls Plasma

  • 2.  van Rossum DB, Barrow RK, Chalkia D, Gessel GS, Burkholder SG, Watkins DN, Snyder SH, and Patterson RL "SLINKE1 (Spring Like IP3-receptor iNteractor for K
  • 3. van Rossum DB, Nikolaidis N, Chalkia D, Makalowski W, Patterson RL "Gestalt Domain Determination Algorithm- Identification of non-canonical functional protein domains." (in preparation for Nucleic Acid
  • 4. van Rossum DB*, Chalkia D*, Nikolaidis N, Barrow RK, Snyder SH, Kiselyov KI, Patterson RL " TRPC3 sensitivity to diacylyglycerol is mediated through a non-canonical ENTH domain." (in preparation for Science 2005). 
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    Research Interests:

    Cell and Developmental Biology:
    Evolutionary Biology:
    Genomics:
    Neuroscience:
    Theoretical and Computational Biology: